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Molecular Oncology

 

Dr. Licio Collavin

Tel: +39-040-398992
Fax: +39-040-398990
email: collavin@lncib.it

- Biosketch -

Graduated in Biological Sciences at the University of Trieste, Licio Collavin obtained his PhD from the International School for Advanced Studies (SISSA) in Trieste, working in the group of prof. Claudio Schneider. He did a three years postdoc in the lab of prof. Marc W. Kirschner, in the Department of Cell Biology at Harvard Medical School, Boston, MA (USA).
Dr. Collavin is now Assistant Professor (Ricercatore) at the University of Trieste, in the Faculty of Medicine.

 
- People in the Collavin lab -
jun 2008
Andrea Lunardi 
Giulio Di Minin
Elisa D'Este
Marco Dal Ferro
 
Past lab members...
 
- Research -

We use the frog Xenopus laevis as a model system to study functional interactions between signaling pathways active during early embryogenesis in vertebrates; these same pathways are frequently affected in human cancer. Within this experimental frame, we try to understand the role played by tumor suppressor genes during development.

 

 
- Ongoing Projects -
 
The fly p53 "interactome"

Mapping the protein interaction profile of Drosophila p53 by small pool screening

This project aims at searching the entire Drosophila genome for proteins that interact with Dmp53 in vitro. The approach involves a small pool based screening of the Drosophila Gene Collection by in vitro pull down, using baculovirus expressed recombinant Dmp53 as a bait. Positive hits will provide a framework to study the corresponding homologues in mammals.
We believe that such an unbiased screening has a good potential to uncover novel, highly conserved molecular circuits regulating this crucial tumor suppressor.

 
A possible role of p53 interacting proteins in vertebrate development

Analysis of the biological function of known and novel proteins which interact with p53 family members; interaction with pathways regulating early embryonic development

Proteins interacting with p53 might be either modulators or effectors of its fundamental functions in regulating the cellular responses to a variety of stimuli. At the same time, these proteins might also have diverse functions in the cell.
The Molecular Oncology Unit has a collection of genes that interact with wild-type p53, tumor derived p53 mutants, and the p53 family member p73. Part of the genes in this collection are published interactors, but there are also several new genes identified by yeast two hybrid screenings. We plan to assay these genes by injection in Xenopus embryos, to test a possible interaction with biological pathways active during early vertebrate development.

 

Molecular Oncology Unit

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