Molecular Oncology

Guida E, Bisso A, Fenollar-Ferrer C, Napoli M, Anselmi C, Girardini JE, Carloni P, Del Sal G. (2008) Peptide aptamers targeting mutant p53 induce apoptosis in tumor cells. Cancer Res, 68(16):6550-8.

Mauri F, McNamee LM, Lunardi A, Chiacchiera F, Del Sal G, Brodsky MH, Collavin L. (2008) Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions. J Biol Chem., 283(30):20848-56.

Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G. (2008) Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood, 111(3):1287-94.

Mantovani F, Tocco F, Girardini J, Smith P, Gasco M, Lu X, Crook T, Del Sal G. (2007) The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP. Nat Struct Mol Biol., 14(10):912-20.

Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R. (2007) Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science, 315(5812):659-63.

Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X. (2006) iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet., 38(10):1133-41.

Gresko E, Roscic A, Ritterhoff S, Vichalkovski A, del Sal G, Schmitz ML. (2006) Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. EMBO J., 25(9):1883-94.

Gostissa, M., Morelli, M., Mantovani, F., Guida, E., Piazza, S., Collavin, L., Brancolini, C., Schneider, C., and Del Sal, G. (2004). The transcriptional repressor hDaxx potentiates p53-dependent apoptosis. J Biol Chem 279, 48013-48023.

Collavin, L., Gostissa, M., Avolio, F., Secco, P., Ronchi, A., Santoro, C., and Del Sal, G. (2004). Modification of the erythroid transcription factor GATA-1 by SUMO-1. Proc Natl Acad Sci U S A 101, 8870-8875.

Mantovani, F., Gostissa, M., Collavin, L., and Del Sal, G. (2004). KeePin' the p53 family in good shape. Cell Cycle 3, 905-911.

Mantovani, F., Piazza, S., Gostissa, M., Strano, S., Zacchi, P., Mantovani, R., Blandino, G., and Del Sal, G. (2004). Pin1 links the activities of c-Abl and p300 in regulating p73 function. Mol Cell 14, 625-636.

Gostissa, M., Hofmann, T. G., Will, H., and Del Sal, G. (2003). Regulation of p53 functions: let's meet at the nuclear bodies. Curr Opin Cell Biol 15, 351-357.

Collavin, L., and Kirschner, M. W. (2003). The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development 130, 805-816.

Zacchi, P., Gostissa, M., Uchida, T., Salvagno, C., Avolio, F., Volinia, S., Ronai, Z., Blandino, G., Schneider, C., and Del Sal, G. (2002). The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 419, 853-857.

D'Orazi, G., Cecchinelli, B., Bruno, T., Manni, I., Higashimoto, Y., Saito, S., Gostissa, M., Coen, S., Marchetti, A., Del Sal, G., et al. (2002). Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4, 11-19.

Sandy, P., Gostissa, M., Fogal, V., Cecco, L. D., Szalay, K., Rooney, R. J., Schneider, C., and Del Sal, G. (2000). p53 is involved in the p120E4F-mediated growth arrest. Oncogene 19, 188-199.

Fogal, V., Gostissa, M., Sandy, P., Zacchi, P., Sternsdorf, T., Jensen, K., Pandolfi, P. P., Will, H., Schneider, C., and Del Sal, G. (2000). Regulation of p53 activity in nuclear bodies by a specific PML isoform. Embo J 19, 6185-6195.

Gostissa, M., Hengstermann, A., Fogal, V., Sandy, P., Schwarz, S. E., Scheffner, M., and Del Sal, G. (1999). Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. Embo J 18, 6462-6471.

Collavin, L., Lazarevic, D., Utrera, R., Marzinotto, S., Monte, M., and Schneider, C. (1999). wt p53 dependent expression of a membrane-associated isoform of adenylate kinase. Oncogene 18, 5879-5888.